lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. due to its long duration of action, lacidipine does not lead to reflex tachycardia. it displays specificity in the vascular smooth muscle, where it
pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. it also possesses sedative and appetite-stimulating properties. pizotifen hydrochloride is an active ingredient in sandomigran, w
memantine hydrochloride is an amantadine derivative that has some dopaminergic effects. memantine hydrochloride has been proposed as an antiparkinson agent.
agomelatine is structurally closely related to melatonin. agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2c (5-ht2c) receptors, tested in an animal model of depression.
fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine). fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
azvudine is a potent nucleoside reverse transcriptase inhibitor (nrti), with antiviral activity on hiv, hbv and hcv. azvudine inhibits nrti-resistant viral strains. azvudine exerts highly potent inhibition on hiv-1 (ec50s ranging from 0.03 to 6.92 nm) and
dasatinib is an orally bioavailable synthetic small molecule-inhibitor of src-family protein-tyrosine kinases. dasatinib binds to and inhibits the growth-promoting activities of these kinases. apparently, because of its less stringent binding affinity for
talipexole dihydrochloride is a dopamine d2 receptor agonist, α2-adrenoceptor agonist, and 5-ht3 receptor antagonist in both rat cortical and intestinal membrane fractions with ki values of 0.35 μm and 0.22 μm, respectively. it displays antiparkinsonian a
balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hv1a) receptor antagonist, with kis of 1 and 39 nm for human (hv1a) and mouse (mv1a) receptors. it is used for the research of autism.
bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase a (itpka). it acts by suppressing the metastasis-promoting effect of itpka in lung tumor cells(with ic50 of 37 μm in adp-glo assay).
bay-2402234 is an inhibitor of dihydroorotate dehydrogenase (dhodh) for the treatment of myeloid malignancies.bay 2402234 is a selective low-nanomolar inhibitor of human dhodh enzymatic activity.
levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active l-isomer of ofloxacin with antibacterial activity. levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase (bacterial topois
bay1082439 is highly effective in inhibiting pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective pi3kα/β/δ inhibitor. bay1082439 also inhibits mutated forms of pik3ca.
axitinib is an orally bioavailable tyrosine kinase inhibitor with ic50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nm for vegfr1, vegfr2, vegfr3, c-kit, and pdgfrβ, respectively.
bi-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on th2 cells (dp2/crth2). with ic50 values of 4.5 nm and 3.7 nm for pgd2 binding to crth2 in hcrth2 and mcrth2 transfected cells, respectively. bi-671800
biotin-dadoo is a biotinylation reagent,which can be used to synthesize a biotin-estradiol conjugate (i.e., biotin-dadoo-estradiol) to develop a direct, broad range enzyme immunoassay to measure plasma estradiol concentrations.
biotin hydrazide is a carbonyl-reactive biotinylation reagent, which is a carbonyl probe. biotin hydrazide is a great choice for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoprotiens.
epalrestat, an aldose reductase inhibitor, is well tolerated in long-term therapy. it can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy
biotin-peg3-acid is a biotin-labeled, peg-based protac linker that can be used in the synthesis of protacs.biotin-peg3-acid is a heterobiofunctional biotin peg derivative containing a carboxylic acid group. the hydrophilic peg spacer arm imparts water sol
captopril is a potent and specific inhibitor of peptidyl-dipeptidase a. it blocks the conversion of angiotensin i to angiotensin ii, a vasoconstrictor and important regulator of arterial blood pressure.
toremifene citrate is a selective estrogen receptor modulator (serm). it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.
motixafortide is an antagonist of cxcr4 with ic50 of ~1 nm. it induces the apoptosis of aml blasts by down-regulating erk, bcl-2, mcl-1 and cyclin-d1 via altered mir-15a/16-1 expression.