其他產(chǎn)品及廠家

PPARγ-IN-2；化合物 PPARγ-IN-2PPARγ-IN-2
"pparγ-in-2 (compound 5a), a pparγ inhibitor, exhibits an ec50 of 0.106 μm in inhibiting tg accumulation in 3t3-l1 preadipocytes. furthermore, pparγ-in-2 counteracts obesity and associated metabolic syndrome induced by a high-fat cholesterol (hfc) diet and diminishes lipid accumulation in adipose tissue [1]."
更新時(shí)間:2025-09-05
PSEN1-IN-1；化合物 PSEN1-IN-1PSEN1-IN-1
psen1-in-1 (compound (+)-13b) functions as an inhibitor of psen1, displaying potent inhibition of the psen1-aph1a and psen1-aph1b complexes with respective ic50 values of 19 nm and 5.5 nm. this compound is utilized in alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
Dazoxiben；達(dá)唑氧苯UK-37248；UK-37248|||達(dá)唑氧苯
dazoxiben (uk-37248) is a potent inhibitor of thromboxane (tx) synthase
更新時(shí)間:2025-09-05
PSEN1-IN-2；化合物 PSEN1-IN-2PSEN1-IN-2
psen1-in-2 (compound 13k) is a potent inhibitor of both psen1-aph1a and psen1-aph1b complexes, exhibiting ic50 values of 6.9 nm and 2.4 nm, respectively. as a psen1 inhibitor, it is utilized in alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
CA inhibitor 2；化合物 CA inhibitor 2CA inhibitor 2
compound 4h is a potent carbonic anhydrase inhibitor with an ic50 value of 0.033 μm [1].
更新時(shí)間:2025-09-05
qsl-304；化合物 qsl-304qsl-304
qsl-304 is a dna gyrase b inhibitor that serves as an antibacterial agent, exhibiting an ic50 of 31.23 mg/ml against staphylococcus aureus sa-p2003 [1].
更新時(shí)間:2025-09-05
HDAC/CD13-IN-1；化合物 HDAC/CD13-IN-1HDAC/CD13-IN-1
hdac/cd13-in-1 (compound 12) is an inhibitor of both hdac and cd13, with ic50 values of 0.34 μm for hcd13, 0.53 μm for porcine cd13, and 0.03, 0.06, and 0.02 μm for hdac1, hdac2, and hdac3, respectively. this compound effectively suppresses the proliferation of mv4-11, k562, jeko-1, and hl60 cancer cells, with ic50 ranges between 0.25-2.04 μm, and also induces apoptosis in these cells. furthermore, hdac/cd13-in-1 demonstrates capabilities in hindering metastasis and invasion [1].
更新時(shí)間:2025-09-05
5-HT6R antagonist 1；化合物 5-HT6R antagonist 15-HT6R antagonist 1
compound 8 (5-ht6r antagonist 1), a 5-ht6r antagonist (k i : 5 nm), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability but also reverses mk-801-induced memory impairments in rats, suggesting its utility in alzheimer´s disease (ad) research [1].
更新時(shí)間:2025-09-05
PI3Kα-IN-13；化合物 PI3Kα-IN-13PI3Kα-IN-13
pi3kα-in-13 (compound 18a), a pi3kα inhibitor with an ic50 of 2.5 nm, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting ic50 values of 0.75 μm (mcf-7), 3.79 μm (hct-116), 13.71 μm (mda-mb-231), and 9.85 μm (sw620). this compound also impedes tumor cell colony formation, migration, and invasion [1].
更新時(shí)間:2025-09-05
FGFR1 inhibitor-10；化合物 FGFR1 inhibitor-10FGFR1 inhibitor-10
fgfr1 inhibitor-10 (compound 4i), with an ic50 of 28 nm, effectively inhibits fgfr1 phosphorylation. this compound demonstrates anti-angiogenic and anti-invasion properties, as well as a significant anti-tumor effect [1].
更新時(shí)間:2025-09-05
TEAD-IN-6；化合物 TEAD-IN-6TEAD-IN-6
tead-in-6 (example 11-1) is a tead modulator that inhibits the yap1/taz-tead interaction, and has applications in cancer research [1].
更新時(shí)間:2025-09-05
FAK-IN-11；化合物 FAK-IN-11FAK-IN-11
fak-in-11 (compound 4l), a fak inhibitor, specifically targets the atp binding pocket of fak to prevent its phosphorylation. it exhibits cytotoxic effects on mda-mb-231 cells, achieving an ic50 value of 13.73 μm, and induces non-apoptotic cell death in these cells [1].
更新時(shí)間:2025-09-05
SIRT6-IN-3；化合物 SIRT6-IN-3SIRT6-IN-3
sirt6-in-3 (compound 8a), a selective sirt6 inhibitor (ic50 = 7.49 μm), impedes the proliferation of pancreatic ductal adenocarcinoma (pdac) cells and prompts apoptosis. it enhances the responsiveness of cancer cells to gemcitabine by obstructing the dna damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
更新時(shí)間:2025-09-05
Dipyrithione；雙吡啶硫酮Dipyrithione
dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity
更新時(shí)間:2025-09-05
FIKK9.1-IN-1；化合物 FIKK9.1-IN-1FIKK9.1-IN-1
fikk9.1-in-1 (compound 1), an antimalarial agent (ic50: 2.68 μg/ml), serves as a fikk9.1 inhibitor by interacting with the atp-binding residues within fikk9.1, thereby disrupting the parasite life cycle and resulting in parasite death [1].
更新時(shí)間:2025-09-05
AChE-IN-40；化合物 AChE-IN-40AChE-IN-40
ache-in-40 (compound 5c), with an inhibitory concentration 50 (ic50) of 120 nm, is an acetylcholinesterase (ache) inhibitor suitable for alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
BChE-IN-19；化合物 BChE-IN-19BChE-IN-19
bche-in-19 (compound 7b), a para-substituted indone derivative, exhibits potent inhibitory activity against butyryl cholinesterase (bche) with an ic50 value of 0.04 μm. it enhances cholinergic neurotransmission and has potential therapeutic application in alzheimer´s disease [1].
更新時(shí)間:2025-09-05
NLRP3-IN-19；化合物 NLRP3-IN-19NLRP3-IN-19；NLRP3-IN-19
jt001 (nlrp3-in-19) is a potent, specific, and orally active nlrp3 inhibitor that impedes the assembly of the nlrp3 inflammasome. this action results in the suppression of cytokine release and prevention of pyroptosis. jt001 is utilized in research on nonalcoholic steatohepatitis and liver fibrosis [1].
更新時(shí)間:2025-09-05
JT001 sodium；化合物 JT001 sodiumNLRP3-IN-19 sodium；NLRP3-IN-19 sodium
jt001 (nlrp3-in-19) sodium is a potent, specific, and orally active nlrp3 inhibitor that impedes the assembly of the nlrp3 inflammasome, thus curbing cytokine release and averting pyroptosis. it is utilized in research focused on nonalcoholic steatohepatitis and liver fibrosis [1].
更新時(shí)間:2025-09-05
Casein kinase 1δ-IN-10；化合物 Casein kinase 1δ-IN-10Casein kinase 1δ-IN-10
casein kinase 1δ-in-10 is an inhibitor of casein kinase 1δ (ck1δ).
更新時(shí)間:2025-09-05
anti-TNBC agent-2；化合物 anti-TNBC agent-2anti-TNBC agent-2
anti-tnbc agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (tnbc) therapeutic. it promotes apoptosis in mda-mb-231 cells, while also inhibiting their migration and angiogenesis. moreover, anti-tnbc agent-2 suppresses tumor growth and metastasis, and downregulates ki67 and cd31 protein expression in tnbc xenograft models. it may be utilized for tnbc research [1].
更新時(shí)間:2025-09-05
7-Ethoxycoumarin；7-乙氧基香豆素7-Ethoxycoumarin
7-ethoxycoumarin, a typical human p450 substrate, is catalyzed by both wild-type and mutant forms of cyp102a1.
更新時(shí)間:2025-09-05
α-Glucosidase-IN-32；化合物 α-Glucosidase-IN-32α-Glucosidase-IN-32
α-glucosidase-in-32 (compound f26) is a reversible, noncompetitive inhibitor of α-glucosidase that is orally active and exhibits an ic50 of 3.07 μm. it forms a complex with α-glucosidase via hydrogen bonding and hydrophobic interactions, inducing conformational and secondary structure changes in the enzyme, thereby inhibiting its activity. this compound is utilized in diabetic disease research [1].
更新時(shí)間:2025-09-05
PI3K-IN-48；化合物 PI3K-IN-48PI3K-IN-48
pi3k-in-48, a pi3k inhibitor, exhibits an ic50 of 1.55 ± 0.18 μm in a549 cells, demonstrating its potency in this context. it induces g0/g1 phase arrest and cell apoptosis, while also down-regulating the expression of p-pi3k and p-akt. this compound is relevant for research into the treatment of human lung cancers [1].
更新時(shí)間:2025-09-05
Nrf2 activator-9；化合物 Nrf2 activator-9Nrf2 activator-9
nrf2 activator-9 (compound d-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of huvec cells induced by oxidized low-density lipoprotein (oxldl) and high glucose (hg). it also protects vascular endothelial cells (vec) from oxldl and hg-induced injury, offering potential therapeutic benefits for the prevention and treatment of atherosclerosis [1].
更新時(shí)間:2025-09-05
LP23；化合物 LP23LP23
lp23, a non-arylmethylamine pd-1/pd-l1 inhibitor (ic 50: 16.7 nm), exhibits anti-tumor activity through the restoration of immune cell function in hepg2/jurkat t cells and induction of hepg2 cell death. additionally, lp23 demonstrates in vivo efficacy in the b16-f10 tumor model (tgi=88.6% at 30 mg/kg) [1].
更新時(shí)間:2025-09-05
Cholicamideβ；化合物 CholicamideβCholicamideβ
cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptide antigens, enhances dendritic cell-mediated antigen presentation and induces antigen-specific t-cell responses, with the ability to induce apoptosis and necrosis [1].
更新時(shí)間:2025-09-05
SSE1806；化合物 SSE1806SSE1806
sse1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and antiproliferative properties. it demonstrates a gi50 for inhibiting cancer cell growth between 1.29-21.15 μm. this compound induces mitotic disruption and g2/m phase arrest, upregulates p53 expression, and suppresses the growth of colon cancer organoids. notably, sse1806 can counteract multidrug resistance in cell lines that overexpress mdr-1 [1].
更新時(shí)間:2025-09-05
PK-10；化合物 PK-10PK-10
pk-10, when combined with fluconazole, exhibits potent synergistic antifungal activity against multiple fluconazole-resistant candida albicans strains. this compound impedes hyphae formation, stimulates reactive oxygen species accumulation, and inflicts mitochondrial membrane potential damage. consequently, pk-10 decreases cellular atp levels and induces mitochondrial dysfunction [1].
更新時(shí)間:2025-09-05
8-Amino-1-Naphthalenesulfonic Acid；周位酸8-Amino-1-Naphthalenesulfonic Acid
8-amino-1-naphthalenesulfonic acid is a naphthalene derivative used as a fluorescent dye and as a reagent in organic synthesis. it is a highly fluorescent compound with a high stokes shift, making it an ideal fluorescent marker for a wide range of biological systems.
更新時(shí)間:2025-09-05
PI3Kα/HDAC6-IN-1；化合物 PI3Kα/HDAC6-IN-1PI3Kα/HDAC6-IN-1
pi3kα/hdac6-in-1 (compound 21j) is a dual inhibitor of pi3kα and hdac6, exhibiting ic50 values of 2.9 nm and 26 nm, respectively. it effectively hinders akt(ser473) phosphorylation and promotes the build-up of acetylated α-tubulin, while not influencing acetylated histones h3 and h4. the compound demonstrates potent anti-cancer efficacy by inhibiting the l-363 cell line with an ic50 of 0.17 μm [1].
更新時(shí)間:2025-09-05
H-Asp(AMC)-OH；化合物 H-Asp(AMC)-OHH-Asp(AMC)-OH
h-asp(amc)-oh, an amino acid derivative and fluorescent dye, does not inhibit glycine transport at a concentration of 0.25 mm [1].
更新時(shí)間:2025-09-05
HAPSBC；化合物 HAPSBCHAPSBC
hapsbc, an s-benzyl iron chelator, modulates the intracellular distribution of ^59fe [1].
更新時(shí)間:2025-09-05
HAP-1；化合物 HAP-1HAP-1
hap-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. when fused with the antimicrobial peptide (klak)2, hap-1 forms the proapoptotic peptide dp2 [1].
更新時(shí)間:2025-09-05
VU0119498；化合物VU0119498VU0119498
vu0119498 is a m1 muscarinic receptor agonist (ec50 = 3.1 μm) and pan machr m3, m5 positive allosteric modulator (pam),and is a neuroprotective agent.
更新時(shí)間:2025-09-05
Haloxyfop-P-methyl；化合物 Haloxyfop-P-methylHaloxyfop-P-methyl
haloxyfop-p-methyl, an aryloxyphenoxypropionate herbicide, is absorbed through both foliage and roots, where it inhibits lipogenesis and induces oxidative stress in susceptible plant species [1].
更新時(shí)間:2025-09-05
Halichondrin B；化合物 Halichondrin BHalichondrin B
halichondrin b, sourced from the sponge halichondria okadai, serves as a noncompetitive inhibitor of vinca-alkaloid binding to tubulin, with an ic 50 for tubulin polymerization ranging from 1.2-1.4 μm, and exhibits anti-tumor activity [1].
更新時(shí)間:2025-09-05
hAChE-IN-6；化合物 hAChE-IN-6hAChE-IN-6
hache-in-6 (compound 51) is a brain-penetrant acetylcholinesterase (ache) inhibitor exhibiting an ic50 of 0.16 μm. it also demonstrates inhibitory effects on human butyrylcholinesterase (hbuche) and glycogen synthase kinase 3 beta (gsk3β), with ic50 values of 0.69 μm and 0.26 μm, respectively. additionally, hache-in-6 impedes the self-aggregation of tau protein and amyloid-beta 1-42 (aβ1-42), rendering it useful for alzheimer´s disease (ad) research [1].
更新時(shí)間:2025-09-05
HA-CD44 interaction inhibitor 2；化合物 HA-CD44 interaction inhibitor 2HA-CD44 interaction inhibitor 2
antitumor agent-108 (compound 5), an inhibitor of the hyaluronic acid (ha)-cd44 interaction, effectively disrupts cancer spheroid integrity and exhibits antiproliferative activity against cancer cells [1].
更新時(shí)間:2025-09-05
HA-CD44 interaction inhibitor 1；化合物 HA-CD44 interaction inhibitor 1HA-CD44 interaction inhibitor 1
antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and cd44, which are involved in tumor progression and invasion. it demonstrates potent antitumor activity, specifically inhibiting mda-mb-231 cells with an ec50 of 0.59 ?m [1].
更新時(shí)間:2025-09-05
H7；化合物 H7H7
h7 is a second near-infrared (nir-ii) fluorophore [1].
更新時(shí)間:2025-09-05
Gymnoside IX；化合物 Gymnoside IXGymnoside IX
gymnoside ix (compound 2), isolated from the methanolic extract of gymnadenia conopsea tubers [1], is a chemical entity that exhibits unique properties.
更新時(shí)間:2025-09-05
Gymnoside I；化合物 Gymnoside IGymnoside I
gymnoside i (compound 1), a glycosidoxybenzyl 2-isobutylmalic acid, exhibits antiallergic properties, particularly in the passive cutaneous allergic reaction (pca) test in mice. it holds potential for research applications in the treatment of asthma, neurasthenia, and chronic hepatitis [1].
更新時(shí)間:2025-09-05
Gymnemanol；化合物 GymnemanolGymnemanol
gymnemanol, a triterpene, is isolated from the plant gymnema sylvestre (gymnema sylvestre).
更新時(shí)間:2025-09-05
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID；2-羥基-3,4-二甲氧基苯甲酸2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
2-hydroxy-3,4-dimethoxybenzoic acid is a natural product.
更新時(shí)間:2025-09-05
Gymconopin C；化合物 Gymconopin CGymconopin C
gymconopin c exhibits antiallergic properties, effectively reducing passive cutaneous anaphylaxis reactions in mouse ears.
更新時(shí)間:2025-09-05
GW274150 dihydrochloride；化合物 GW274150 dihydrochlorideGW274150 dihydrochloride
gw274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (inos), exhibiting oral activity and nadph-dependence with an ic50 of 2.19 μm and kd of 40 nm for human inos, and an ed50 of 1.15 μm for rat inos. it demonstrates reduced effectiveness against endothelial nos (enos) and neuronal nos (nnos) in both species. the compound has been shown to confer protective effects in acute lung injury inflammation models [1] [2] [3].
更新時(shí)間:2025-09-05
GTPγS tetralithium；化合物 GTPγS tetralithiumGTPγS tetralithium
gtpγs (tetralithium) is a g-protein activator known for its role in preventing proteolytic degradation of proteins, facilitating tyrosine kinase-dependent glut4 translocation, stimulating phospholipases, and promoting actin polymerization. it is utilized to couple with g-protein α for the investigation of kinase activity effects and serves as a component of lysis buffer [1] [2] [3] [4].
更新時(shí)間:2025-09-05
GSPT1 degrader-2；化合物 GSPT1 degrader-2GSPT1 degrader-2
gspt1 degrader-2 is a potent degrader of gspt1 [1].
更新時(shí)間:2025-09-05
GSK-LSD1；化合物 GSK-LSD1GSK-LSD1
gsk-lsd1, an lsd1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. additionally, it mitigates non-alcoholic fatty liver disease (nafld) and suppresses cytokine release induced by sars-cov-2 in covid-19 peripheral blood mononuclear cells (pbmcs). furthermore, gsk-lsd1 inhibits the proliferation and spread of cancer [1] [2] [3].
更新時(shí)間:2025-09-05

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